Investment Case Modus Therapeutics

Investment case Modus Therapeutics: Significant potential with proven technology

7 jul 2021

Read the full report here (ENG):

Investment case Modus 7 July 2021


Drug candidate and areas of use

Modus has developed a drug candidate, sevuparin, for sepsis, or blood poisoning. Sepsis is a deadly disease that in its most dangerous stage, septic shock, has a mortality rate of about 30 percent for sick patients. There are no approved specific drugs against the condition, which thus categorizes the condition as an area of great unmet medical need. In septic shock, the permeability of organs’ blood vessels increases to extreme levels, causing them to be flooded with body fluids. This in turn leads to organ failure with devastating consequences for the patient. Sevuparin is thought to prevent the permeability of blood vessels from increasing in shock, which would prevent organ failure and drastically reduce mortality in sepsis and septic shock. Sevuparin is based on heparin, a drug from the 1930s that inhibits the blood’s ability to clot. Thus, many of the candidate’s characteristics are already known, which reduces the development risk.

Good clinical data from earlier studies

Sevuparin has already undergone a phase 2 trial in sickle cell anemia, which showed no effect. Thus, comprehensive safety data is already available. Phase 1 has already been completed with sevuparin with successful results. In principle, the company is currently ready for a phase 2 trial. However, the management believes that an initial phase 1b trial on healthy volunteers with simulated illness is a safer way to go than to start the phase 2a trial immediately. This is because such a phase 1b trial can provide information about the optimal dosage.

Great potential with significant risks

Although the company is in principle ready for a phase 2 trial, it is listed on a stock exchange as a preclinical company. This can be partly explained by the fact that the patent-protected period is relatively short and runs until 2032. However, the company expects to receive an extension of the patent until 2036-2037. The relatively short patent period is due to previously unsuccessful studies in the sickle cell track that cost the company several years in terms of development time within the then indication. However, it is not uncommon for drugs to find new uses during research, especially when they have such broad mechanisms of action that sevuparin could potentially be targeted. Overall, Modus pre-money valuation is clearly lower than the average for research companies in phase 1/2.

Great potential with significant risks

odus as an investment, like many other companies in the sector, is associated with big risks. In addition to the patentsituation, additional financing will probably be needed before outlicensing the candidate or selling the company. Despite this, we estimate a fair value of SEK 234 million, pre-money. This can be put in relation to the current offer with a pre-money valuation of SEK 70 million.


Disclaimer

Carlsquare AB, www.carlsquare.se, hereinafter referred to as Carlsquare, conducts business with regard to Corporate Finance and Equity Research in which areas it, among other things, publishes information about companies including analyzes. The information has been compiled from sources that Carlsquare considers to be reliable. However, Carlsquare cannot guarantee the accuracy of the information. Nothing written in the analysis should be regarded as a recommendation or invitation to invest in any financial instrument, option or the like. Opinions and conclusions expressed in the analysis are intended only for the recipient. The content may not be copied, reproduced or distributed to another person without the written approval of Carlsquare. Carlsquare shall not be held responsible for any direct or indirect damage caused by decisions made on the basis of information contained in this analysis. Investments in financial instruments provide opportunities for value increases and profits. All such investments are also subject to risks. Risks vary between different types of financial instruments and combinations of these. Historical returns should not be considered as an indication of future returns. The analysis is not directed to U.S. persons (as defined in Regulation S of the United States Securities Act and interpreted in the United States Investment Company Act 1940) nor may it be disseminated to such persons. The analysis is also not directed to such natural and legal persons where the distribution of the analysis to such persons would result in or entail a risk of a violation of Swedish or foreign law or constitution. The analysis is a so-called Commissioned Research Report where the analyzed Company has signed an agreement with Carlsquare for analysis coverage. The analyzes are published on an ongoing basis during the contract period and for a usual fixed remuneration. Carlsquare may or may not have a financial interest in the subject of this analysis. Carlsquare values the assurance of objectivity and independence and has established procedures for managing conflicts of interest for this purpose. The analysts Jonatan Andersson, Richard Ramanius and Ulf Boberg does not own and is not allowed to own shares in the
company analyzed.


 

Team

Bild av Jessica Algner
Jessica Algner

Assistant

Telefon: +49 30 809 33 47-12

LinkedIn

@

Bild av Polina Amini
Polina Amini

Senior Associate

Telefon: +49 40 300 836-14

LinkedIn

@

Bild av Jonatan Andersson
Jonatan Andersson

Equity Analyst

Telefon: +46 70 508 00 51

LinkedIn

@

Bild av Markus Augustsson
Markus Augustsson

Head of Equity Research

Telefon: +46 76 235 03 20

LinkedIn

@

Bild av Agata Barsallo
Agata Barsallo

Office Management & Accounting

Telefon: +44 20 8017 6020

@

Bild av Caroline Berglund
Caroline Berglund

Head of Equity Sales

Telefon: +46 73 382 10 82

LinkedIn

@

Bild av Anders Bo
Anders Bo

Managing Partner

Telefon: +45 4199 8252

LinkedIn

@

Bild av Ulf Boberg
Ulf Boberg

Senior Advisor Life Sciences

Telefon: +46 73 312 44 90

LinkedIn

@

Bild av Manfred Drax
Manfred Drax

Partner

Telefon: +49 89 255 49 53-15

LinkedIn

@

Bild av Anders Elgemyr
Anders Elgemyr

Managing Partner

Telefon: +46 70 496 18 15

LinkedIn

@

Bild av Sebastian Fischer
Sebastian Fischer

Director

Telefon: +49 89 255 49 53-12

LinkedIn

@

Bild av Daniel Garlipp
Daniel Garlipp

Managing Partner

Telefon: +49 40 300 836-19

LinkedIn

@

Bild av Philip Goldhahn
Philip Goldhahn

Vice President

Telefon: +49 40 300 836-21

LinkedIn

@

Bild av Thorsten Grandt
Thorsten Grandt

Vice President

Telefon: +49 30 809 33 47-20

LinkedIn

@

Bild av Johan Heigard
Johan Heigard

Vice President

Telefon: +46 70 246 99 88

LinkedIn

@

Bild av Caroline Heintz
Caroline Heintz

Senior Associate

Telefon: +46 707 40 68 58

@

Bild av Maurice Hinrichs
Maurice Hinrichs

Associate

Telefon: +49 40 300 836-20

LinkedIn

@

Bild av Arnold Holle
Arnold Holle

Managing Partner

Telefon: +44 20 80176020

LinkedIn

@

Bild av Lars Johansen
Lars Johansen

IT&Telecom Expert

@

Bild av Elaine Kelly
Elaine Kelly

Head of Marketing

Telefon: +49 40 300 836 18

LinkedIn

@

Bild av Anna-Lena Kickbusch
Anna-Lena Kickbusch

Office Management & Accounting

Telefon: +49 40 300 836 10

LinkedIn

@

Bild av Morten Kjærulff
Morten Kjærulff

Partner

Telefon: +45 2634 9031

LinkedIn

@

Bild av Mischa Krause
Mischa Krause

Director

Telefon: +49 40 300 836-24

LinkedIn

@

Bild av Steffen Leckert
Steffen Leckert

Managing Partner

Telefon: +49 89 255 49 53 26

LinkedIn

@

Bild av Malve Liebig
Malve Liebig

Senior Associate

Telefon: +49 89 255 49 53-18

LinkedIn

@

Bild av Erik Lundberg
Erik Lundberg

Partner

Telefon: +46 73 850 35 59

LinkedIn

@

Bild av Eva Macha
Eva Macha

Office Management & PA to Michael Moritz

Telefon: +49 30 809 33 47-10

LinkedIn

@

Bild av Mandy May
Mandy May

Head of Operations

Telefon: +49 30 809 33 47 16

LinkedIn

@

Bild av Mirja Meyer
Mirja Meyer

Office Management & Accounting

Telefon: +49 40 300 836 10

@

Bild av Mark Miller
Mark Miller

Managing Partner

Telefon: +49 40 300 836-11

LinkedInXING

@

Bild av Michael Moritz
Michael Moritz

Managing Partner

Telefon: +49 30 809 33 47-13

LinkedIn

@

Bild av Bertil Nilsson
Bertil Nilsson

Senior Equity Analyst

Telefon: +46 70 434 90 03

LinkedIn

@

Bild av Flemming C. Pedersen
Flemming C. Pedersen

Managing Partner

Telefon: +45 4199 8251

LinkedIn

@

Bild av Anika Schaefer
Anika Schaefer

Office Management & HR

Telefon: +49 89 255 495 310

@

Bild av Alexander Schleppegrel
Alexander Schleppegrel

Associate

Telefon: +45 2621 0543

LinkedIn

@

Bild av Nico Schmidt-Weidemann
Nico Schmidt-Weidemann

Managing Partner

Telefon: +49 89 255 49 53-17

@

Bild av Caspar Graf Stauffenberg
Caspar Graf Stauffenberg

Managing Partner

Telefon: +49 89 255 49 53-11

LinkedIn

@

Bild av Gregor Steins
Gregor Steins

Senior Associate

Telefon: +49 40 300 836-15

LinkedIn

@

Bild av Jon Tingling
Jon Tingling

Vice President

Telefon: +44 77 1347-8286

LinkedIn

@

Bild av Sybille de Vegvar
Sybille de Vegvar

Business Development & Marketing

Telefon: +44 20 8017 6017

@

Bild av Oskar Wollert
Oskar Wollert

Vice President

Telefon: +46 761 71 11 60

@

Bild av Nils Zettelmeyer
Nils Zettelmeyer

Director

Telefon: +49 30 809 33 47-25

LinkedIn

@

Bild av Andreas Zetzsche
Andreas Zetzsche

Partner

Telefon: +49 30 809 3347 33

@

Bild av Marta Zientarski
Marta Zientarski

Vice President

Telefon: +46 73 840 55 66

@

Bild av Gerrit Zwarg
Gerrit Zwarg

Senior Associate

Telefon: +49 40 300 836-28

LinkedIn

@